Technical Data
Claudin 4 (Claudin-4, CLDN4, Clostridium perfringens Enterotoxin Receptor, CPE-receptor, CPER, CPE-R, hCPE-R, CPETR, CPETR1, Williams-Beuren Syndrome Chromosomal Region 8 Protein, WBSCR8)
Claudin-4 is a member of the claudin family and one of the integral constituents of tight junctions. Tight junctions are the most apical component of intercellular junctional complexes, thereby establishing cell polarity and functioning as major determinants of paracellular permeability. Claudin-4 is overexpressed in the majority of pancreatic carcinomas and functions as a receptor for cytotoxic CPE. It consists of 209 amino acids and contains four putative transmembrane segments. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.

Suitable for use in Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 1:100-1:200
Optimal dilutions to be determined by the researcher.

Positive Control:
Ovarian carcinoma, tonsil

Cellular Localization:
Cytoplasmic and cell membrane

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
500ul-20CBlue IceHumanRabbit
Not determined
Synthetic peptide corresponding to C-terminal of human Claudin 4.
Supplied as a liquid in 0.05% sodium azide.
Recognizes human Claudin 4. Species Crossreactivity: mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Patrick et al. Cancer Research 63: 6265, 2003.