Technical Data
CLEC4D (C-type Lectin Domain Family 4, Member D, C-type Lectin Superfamily Member 8, C-type Lectin-like Receptor 6, CLEC-6, CLECSF8, MCL) (PE)
CLEC4D (C-type lectin domain family 4 member D), also known as CLCSF8, CLEC-6, and MCL, is a 30kD type II transmembrane (TM) glycoprotein that belongs to the CLR (C-type Lectin Receptor) family of molecules. It is synthesized as a 215aa protein that contains a 17aa N-terminal cytoplasmic domain, a 21aa TM segment, and a 177aa C-terminal extracellular region. The extracellular region shows a short stalk and a 118aa CRD (carbohydrate recognition domain). The nature of its carbohydrate ligand is unknown. CLEC4D is restricted to monocytes/macrophages and serves as an endocytic receptor. Homodimers and homotrimers form on the cell surface.

Suitable for use in Flow Cytometry, ELISA and Western Blot. Other applications not tested.

Recommended Dilutions:
Flow Cytometry: 10ul/10e6 cells, human periferal blood monocytes
Optimal dilutions to be determined by the researcher.

Myeloma with B cells from Balb/c mice.

Storage and Stability:
Store product at 4C in the dark. DO NOT FREEZE! Stable at 4C for 12 months after receipt as an undiluted liquid. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
MabIgG2b11C7Affinity Purified
100Tests4C Do Not FreezeBlue IceHumanMouse
Purified, NS0-derived, recombinant human CLEC4D (aa52-215; Accession # Q8WXI8).
Purified by Protein A/G affinity chromatography.
Supplied as a liquid in sodium chloride, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
Recognizes human CLEC4D. Does not cross react with rhCLECSF9, rhCLECSF13, rhOCIL or rhOCILrp2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.