Technical Data
C5845
Clonidine
Description:
Clonidine is a centrally-acting alpha-adrenergic receptor agonist with more affinity for alpha2 than alpha1. It selectively stimulates receptors in the brain that monitor catecholamine levels in the blood. These receptors close a negative feedback loop that begins with descending sympathetic nerves from the brain that control the production of catecholamines (epinephrine, also known as adrenaline, and norepinephrine) in the adrenal medulla. By fooling the brain into believing that catecholamine levels are higher than they really are, clonidine causes the brain to reduce its signals to the adrenal medulla, which in turn lowers catecholamine production and blood levels. The result is a lowered heart rate and blood pressure, with side effects of dry mouth and fatigue. If clonidine is suddenly withdrawn the sympathetic nervous system will revert to producing high levels of epinephrine and norepinephrine, higher even than before treatment, causing rebound hypertension. Rebound hypertension can be avoided by slowly withdrawing treatment.

Applications:
Suitable for use in Immunoprecipitation. Other applications not tested.

Recommended Dilution:
Immunoprecipitation: 1:3200
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
500ul-20CBlue IceRabbit
Concentration:
Neat serum
Immunogen:
Clonidine-BSA
Purity:
Serum.
Form
Supplied as a liquid. No preservatives added.
Specificity:
Recognizes Clonidine: 100%.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.