Technical Data
CFB, ID (Complement Factor B, C3/C5 Convertase, Properdin Factor B, Glycine-rich beta Glycoprotein, GBG, PBF2, Complement factor B Ba fragment, Complement factor B Bb fragment, BFD, BF)
CFB encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.

Suitable for use in ELISA, Immunohistochemistry and Flow Cytometry and Western Blot. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry (FFPE): 1:50-1:100
Flow Cytometry: 1:10-1:50
Western Blot: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
200ul-20CBlue IceHumanRabbit
As Reported
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 469-494 in the central region of human CFB, UniProt Accession #P00751.
Purified by Protein A affinity chromatography.
Supplied as a liquid in PBS, 0.09% sodium azide.
Recognizes human CFB. Species Crossreactivity: mouse
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Munch,I.C.,, Invest. Ophthalmol. Vis. Sci. (2009) In press. 2. Gateva,V.,, Nat. Genet. 41(11), 1228-1233 (2009).