Technical Data
Concanamycin A (Folimycin, Antibiotic TAN 1323B)
Biochemicals Storage: -20CShipping: Blue Ice
Concanamycin A is the major analogue of the concanamycin complex produced by Streptomyces sp. It has has been shown to act as a potent and specific vacuolar-APTase inhibitor. Concanamycin A inhibits the acidification of organelles and blocks cell surface expression of viral envelope glycoproteins without affecting their synthesis. It also interferes with intracellular protein trafficking and inhibits perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Concanamycins are structurally related to the bafilomycins.

Purity: >99% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO

Related to: Bafilomycin A1, Bafilomycin B1, Bafilomycin C1

Storage and Stability: Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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Form: Supplied as a lyophilized powder.

Source: Streptomyces sp.

Purity: ~90% by HPLC

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells. Robinson D.G. et al. Protoplasma 2004, 224, 255. 2. Concanamycin A, a powerful tool for characterization and estimation of contribution of perforin- and Fas-based lytic pathways in cell-mediated cytotoxicity. Kataoka T. et al. J. Immunol. 1996, 156, 3678. 3. Specific inhibitors of vacuolar type H(+)-ATPases induce apoptotic cell death. Nishihara T. et al. Biochem. Biophys. Res. Commun. 1995, 212, 255. 4. Folimycin (concanamycin A), a specific inhibitor of V-ATPase, blocks intracellular translocation of the glycoprotein of vesicular stomatitis virus before arrival to the Golgi apparatus. Muroi M. et al. Cell Struct. Funct. 1993, 18, 139.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.