Technical Data
C7949-06A
Cullin 1, CT (CUL1, Cullin-1, CUL-1)
Description:
Cullin-1 is a negative regulator of the cell cycle that controls the abundance of G1 cyclins during embryogenesis; Cul1 mutants produce abnormally small cells due to an accelerated progression of the cell cycle G1-to-S-phases and the absence of mitotic arrest phase. Null mutations cause hyperplasia of all tissues. Cul-1 is part of the SCF ubiquitin ligase complex with S KP1 and F box-containing protein. Cul-1 is homologous to the yeast cdc53 protein.

Applications:
Suitable for use in Western Blot, ELISA, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
ELISA: 1:2000-1:10,000
Western Blot: 1:500-1:1000
Immunohistochemistry (Formalin fixed paraffin embedded): 1:500
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabSerum
SizeStorageShippingSourceHost
50ul-20°CBlue IceHumanRabbit
Concentration:
Not determined
Immunogen:
Synthetic peptide corresponding to aa742-752 of human Cullin 1 at C-terminal (KLH).
Purity:
Serum
Form
Supplied as a liquid, 0.1% sodium azide.
Specificity:
Recognizes human Cullin 1. Species sequence homology: Mouse.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.