Technical Data
C8300P
CX3CR1, NT, Blocking Peptide (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28)
50ug
Molecular Biology Storage: -20CShipping: Blue Ice
Peptide corresponding to aa2-21 of human CX3CR1 (1). The sequence differs from those of mouse and rat CX3CR1 by four amino acids (3,4). CX3CR1 is one of the chemokine receptors that is required as a coreceptor for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively, (1-4). The encoded seven transmembrane proteins were recently identified as the receptors for a novel transmembrane molecule, fractalkine, and renamed CX3CR1 (5). Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine (6). CX3CR1 mediates leukocyte migration and adhesion (5). CX3CR1 is expressed in a variety of human tissues and cell lines (2).

AA Sequence: DQFPESVTENFEYDDLAEAC

Applications:
Suitable for use in ELISA and Antibody Blocking. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
For long-term storage, aliquot and store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source: Synthetic peptide
Concentration: ~0.2mg/ml
Form: Supplied as a liquid in PBS, pH 7.2, 0.1% BSA, 0.02% sodium azide.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Raport, C.J., et al., Gene 163: 295-299 (1995). 2. Combadiere, C., et al., DNA Cell Biol. 14: 673-680 (1995). 3. Combadiere, C., et al., Biochem. Biophys. Res. Commun. 253: 728-732 (1998). 4. Harrison, J.K., et al., Neurosci. Lett. 169: 85-89 (1994). 5. Imai, T., et al., Cell 91: 521-530 (1997). 6. Combadiere, C., et al., J. Biol. Chem. 273: 23,799-23,804 (1998).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.