Technical Data
C8348-04B
CXCR2
Description:
Chemokine (Chemoattractant Cytokines) are small peptides that are potent activators and chemo-attractants for leukocyte subpopulations and other non-hemopoietic cells. Chemokine receptors (CXCR) belong to the super-family of G protein-coupled receptors (GPCR), which regulate the trafficking and activation of leukocytes, and operate as co-receptors in the entry of HIV-1 and proliferation and migration of immature neurons, glia and their precursors. Furthermore, chemokine receptors participate in the etiology and progression of various brain disorders, including AIDS dementia, neuro-inflammatory disease and neuroplasia, making them important potential therapeutic targets in these cases several subtypes of CXCR have been characterized.

Applications:
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500
Immunoprecipitation: 1:250
Immunohistochemistry: Frozen
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to the C-terminal region of CXCR2. Cellular Localization: Integral membrane protein.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid, 0.02% sodium azide.
Specificity:
Recognizes CXCR2 expressed on intestinal microvascular cells at ~55kD. Species Crossreactivity: human, mouse, rat .
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Onan, D., Allan, E.H., Quinn, J.M.W., et al. Endocrinology (2009) 150:2244-2253.