Technical Data
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicllium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of the tumor necrosis factor alpha (TNF)-induced replication of human immunodeficiency virus (HIV). Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite.

Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Penicillium sp.
Purity: >99%
Form: White solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Studies in the biochemistry of microorganisms. 93. Cyclopenin, a nitrogen-containing metabolic product of Penicillium cyclopium Westling. Bracken A. et al. Biochem J. 1954, 57, 587. 2. Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumour necrosis factor alpha-induced human immunodeficiency virus replication. Heguy A. et al. Antivir. Chem. Chemother. 1998, 9, 149.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.