Technical Data
C8845-50
Cyclopenin
5mg
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Technical Data |
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C8845-50 |
Cyclopenin |
5mg |
| Biochemicals | Storage: 4°C/-20°CShipping: Blue Ice |
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Cyclopenin is one of an unusual family of benzodiazepine metabolites produced by a number of Penicllium species. Often mistakenly referred to as a mycotoxin, cyclopenin shows little toxicity against mammalian cells, bacteria or fungi in vitro. Cyclopenin is an intermediate in the biosynthesis of 3-O-methyl viridicatin, a strong inhibitor of the tumor necrosis factor alpha (TNF)-induced replication of human immunodeficiency virus (HIV). Lack of availability has hitherto restricted a more intensive investigation of this interesting metabolite. Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility CAS Number: 19553-26-5 Molecular Formula: C17H14N2O3 Molecular Weight: 294.30900000000002592 |
Source: Penicillium sp. Purity: >99% Form: White solid Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Studies in the biochemistry of microorganisms. 93. Cyclopenin, a nitrogen-containing metabolic product of Penicillium cyclopium Westling. Bracken A. et al. Biochem J. 1954, 57, 587. 2. Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumour necrosis factor alpha-induced human immunodeficiency virus replication. Heguy A. et al. Antivir. Chem. Chemother. 1998, 9, 149.
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