Technical Data
CYPC (Peptidyl-prolyl Cis-trans Isomerase C, PPIase C, Cyclophilin C, Rotamase C, PPIC)
Cyclophilin C (CyPC, also Rotamase C and peptidyl-prolyl cis-trans isomerase C) is a 17-23kD member of the cyclophilin-type PPIase family of molecules. It is known to be a Mg2+-dependent intracellular enzyme that can degrade DNA into 50 kb fragments. It also has the potential to interact extracellularly with OPN and activate CD147/EMMPRIN. Human CyPC is 212aa in length. It contains one cyclophilin type PPIase domain (aa41-198). Over aa31-182, human CyPC shares 95aa identity with mouse CyPC, 59%, 79%, 58% aa identity with human CyPA, B and D, respectively.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20C. Reconstituted product is stable for 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
100ug-20CBlue IceHumanSheep
Not determined
Recombinant corresponding to aa31-182 from human Cyclophilin C expressed in E. coli (P45877).
Purified by immunoaffinity chromatography.
Supplied as a lyophilized powder in PBS, Trehalose. Reconstitute with sterile PBS to 200ug/ml.
Recognizes human Cyclophilin C. Species sequence homology: recombinant human Cyclophilin A, rhCyclophilin A-Like 4, rhCyclophilin B, rhCyclophilin E and rhCyclophilin F (1%).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.