Technical Data
C8900-01
Cyclosporin A (Antibiotic S 7481F1, Ciclosporin A, Ramihyphin A, CsA)
Description:
Cyclic hydrophobic oligopeptide isolated from the filamentous fungi, Tolypocladium inflatum, with potent immunosuppressant properties. Induces apoptosis in rat thymocytes and in murine B cell lymphoma cells, but prevents apoptosis in BLB cell lines induced by anti-IgM and ionomycin.The complex of cyclosporin A with cyclophilin inhibits T-cell receptor signal transduction pathway via the inhibition of calcineurin (protein phosphatase 2B) with nanomolar affinity (Ki270nM). Cyclosporin A inhibits interleukin-1a-, lipopolysaccharide- and TNF-a-nitric oxide synthesis induction.

Applications:
Suitable for use in ELISA. Other applications have not been tested.

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Kd: 1x10e-8 L/mol

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG11.BB.884Affinity Purified
SizeStorageShippingSourceHost
1mg-20CBlue IceMouse
Concentration:
~2mg/ml
Immunogen:
Cyclosporin C (BSA coupled). Cyclosporin C is a derivative of Cyclosporin A.
Purity:
Purified by Protein G affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Specificity:
Recognizes Cyclosporin A in buffer solutions and whole blood extracts.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.