Technical Data
C8900-04B
Cyclosporin A (Ciclosporin, Cyclorin, Neoral, Ramihyphin A, Sandimmun, Sandimmune, OL 27-400, S 7481F1, CyA, Antibiotic S 7481F1)
Description:
Cyclosporin A is a widely-used immunosuppressant drug from the fungus Tolypocladium inflatum. Cyclophilins are a highly conserved family of peptidylprolyl cis-trans-isomerases (PPIA) that are targets of the immunosuppressant drug cyclosporin A (CsA). The complex of cyclophilin and CsA can bind to and inhibit calcineurin which leads to inhibition of the transcription factor NFAT and decreased production of cytokines. As isomerases, cyclophilins have been proposed to aid in protein folding. Cyclophilin A can bind to the p55 Gag protein of HIV and appears necessary for HIV infection. There is also some evidence that cyclophilins can have nuclease activity and play a role in apoptosis.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilutions:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG110B2312Affinity Purified
SizeStorageShippingSourceHost
200ug-20CBlue IceMouse
Concentration:
~3.5mg/ml
Immunogen:
Cyclosporin A conjugated to an HMW carrier
Purity:
Purified by protein G affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.5, 0.09% sodium azide.
Specificity:
Recognizes Cyclosporin A.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.