Technical Data
C9011-01G
Cytomegalovirus (CMV)
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Technical Data |
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C9011-01G |
Cytomegalovirus (CMV) |
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Description: Human cytomegalovirus is a ubiquitous herpes virus. The primary infection usually occurs in childhood where it most often is asymptomatic. After initial exposure, the virus establishes a life-long infection. In neonates, and in immunocompromised individuals, such as AIDS patients and transplant recipients, HCMV can cause severe life-threatening infections, and it is the most common cause of viral birth defects. Antibody CCH2 reacts with an early nuclear protein identical with the non-structural DNA-binding protein p52. Antibody DDG9 reacts with an immediate early nuclear protein of about 76kD. For both antibodies, the reactivity persists also at later stages during the HCMV infection where the localization is less distinctly nuclear and appears to be in the cytoplasm. Laser confocal microscopy, however, shows that the reaction is limited to the nuclear membrane. The antibodies do not cross-react with adenovirus, herpes simplex virus, and varicella zoster virus. Applications: Suitable for use in Immunofluorescence, Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:10-1:25 Immunohistochemistry: Frozen Optimal dilutions to be determined by the researcher. Positive Control: Infected lung Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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