Technical Data
CYP2C8, NT (S-mephenytoin 4-hydroxylase, Cytochrome P450 IIC2, P450 Cytochrome MP-12/MP-20, Cytochrome P450 Form 1, CYPIIC8, Cytochrome P450 2C8)
CYP2C8 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol.

Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
200ul-20CBlue IceHumanRabbit
As reported
Synthetic peptide selected from the N-terminal region of human CYP2C8 (KLH).
Purified by ammonium sulfate precipitation.
Supplied as a liquid in PBS, 0.09% sodium azide.
Recognizes human CYP2C8.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1.Adjei,G.O., Antimicrob. Agents Chemother. 52(12), 4400-4406 (2008). 2.Aquilante,C.L., Hum. Genomics 3(1), 7-16 (2008). 3.Nelson,D.R., Pharmacogenetics 14(1), 1-18 (2004).