Technical Data
C9095-16S
Cytochrome P450 (CYP2C8, CYP2C9, CYP2C19, Rat CYP2C12)
Description:
The cytochrome P450 (P450) superfamily of enzymes is one of three enzyme systems which metabolize the fatty acid Arachadonic Acid (AA) to regulators of vascular tone. P450 enzymes are monooxygenase enzymes which require several co-factors such as mNADPH and P-450 reductase. There are over 200 known genes which encode P450s. Epoxygenases are those P450s which metabolize AA to epoxyeicosatrienoic acid (EETs) and w-hydroxylases are those P450s which produce 19- and 20-hydroxyeicosatetraenoic acids (19- and 20-HETE). The cytochrome P450 2A subfamily has been divided into two groups: steroid metabolizing and xenobiotic metabolizing enzymes. P450 2A6 belongs to the xenobiotic metabolizing group catalyzing the oxidation of coumarin, cotinine, aflatoxin B1, and other carcinogenic and precarcinogenic drugs.

Applications:
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not Determined
Immunogen:
Synthetic peptide corresponding to human Cytochrome P450.
Purity:
Serum
Form
Supplied as a liquid. No preservatives added.
Specificity:
Recognizes cytochrome P450 CYP2C8, CYP2C9 and CYP2C19 in human hepatic microsomal fraction and CYP2C12 in rat hepatic microsomal fraction.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.