		Technical Data
C9095-29B	CYP26A1, ID (Cytochrome P450, Family 26, Subfamily A, Polypeptide 1, Cytochrome P450, 26A1, Retinoic Acid-metabolizing Cytochrome, Cytochrome P450 Retinoic Acid-Inactivating 1, Cytochrome P450RAI, hP450RAI, Retinoic Acid 4-hydroxylase, CYP26, P450RAI1)

Description:
CYP26A1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.This endoplasmic reticulum protein acts on retinoids, including all-trans-retinoic acid (RA), with both 4-hydroxylation and 18-hydroxylation activities. This enzyme regulates the cellular level of retinoic acid which is involved in regulation of gene expression in both embryonic and adult tissues.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
ELISA: 1:1,000
Western Blot: 1:50-1:100
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Rabbit

Concentration:

~0.25mg/ml

Immunogen:

Synthetic peptide selected from the center region of human CYP26A1 (KLH).

Purity:

Purified by ammonium sulfate precipitation.

Form

Supplied as a liquid in PBS, 0.09% sodium azide.

Specificity:

Recognizes human CYP26A1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Quere,R., Blood 109(10), 4450-4460 (2007). 2. Lee,S.J., Pharmacogenet. Genomics 17(3), 169-180 (2007). 3. Heise,R., J. Invest. Dermatol. 126(11), 2473-2480 (2006).