Technical Data
C9097-14C
Cytokeratin 14
Description:
Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight from between 40kD and 68kD and isoelectric pH between 4.9 7.8, The individual cytokeratin polypeptides are designated 120. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies

Applications:
Western blot
Immunohistochemistry on frozen tissue sections.
Immunocytochemistry
Flow cytometry
TypeIsotypeCloneGrade
MabIgG32Q1116Purified
SizeStorageShippingSourceHost
100ug4C Do Not FreezeBlue IceHumanMouse
Concentration:
~1mg/ml
Immunogen:
Cytoskeletal preparation of TR146 epithelial cells.
Purity:
Purified IgG from culture supernatant.
Form
Supplied as a liquid in buffer with 0.1% sodium azide.
Specificity:
Reacts with basal cell compartments of stratified and combined epithelia. Recognizes human, porcine, rat and canine cytokeratin 14. Has not been tested on other species.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Wetzels, RHW. et al. Basal cell-specific and hyperproliferation-related keratins in human breast cancer. Am. J. Path. (1991) 138:751763. 2. Wetzels, RHW. et al. Laminin and type VII collagen distribution in different types of human lung carcinomas. Correlation with expression of keratins 14, 16, 17 and 18. Histopathol. (1992) 20:295303.