Technical Data
D0900-19B
DAB2 (Disabled Homolog 2, Mitogen-responsive Phosphoprotein (Drosophila), DOC2, DOC-2)
Description:
Dab2 (Disabled homolog 2, Diabled-2) is a mammalian structural homolog of Drosophila Disabled protein and a mitogen-responsive phosphoprotein (1). As a component of the CSF1 signal transduction pathway, Dab2 is normally expressed in ovarian epithelia cells. However, in
ovarian carcinoma, Dab2 expression is either lost or down- regulated. Therefore, Dab2 is speculated to be a negative regulator of growth and its down-regulation considered to play critical role in ovarian carcinogenesis (2).

Applications:
Suitable for use in Flow Cytometry, Western Blot and Immunoprecipitation. Other applications not tested.

Recommended Dilution:
Flow Cytometry: 1:50
Western Blot: 1:1000-1:5000
Immunoprecipitation: 1:10
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG9H342Supernatant
SizeStorageShippingSourceHost
100ul-20°CBlue IceHumanRabbit
Concentration:
As reported
Immunogen:
A synthetic peptide corresponding to residues in human Dab2.
Purity:
Supernatant
Form
Supplied as a liquid in 50mM Tris-Glycine (pH 7.4), 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA.
Specificity:
Recognizes human Dab2.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Morris SM., et al. EMBO J. 21:1555 2. Sheng Z., et al. Oncogene 19:4847 3. Mok SC., et al. Gynecol. Oncol. 52:247