		Technical Data
D1500-01A	DcR2 (TRAIL-R4, TRUNDD, Decoy Receptor2, TNF receptor related receptor for TRAIL, TNFRSF10D, TRAIL receptor 4, TRAIL receptor with a truncated death domain, TRUNDD, Tumor necrosis factor receptor superfamily member 10D precursor)

Description:
Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.

Applications:
Suitable for use in Flow Cytometry, Immunocytochemistry, Immunohistochemistry and Immunoprecipitation. Other applications have not been tested.

Recommended Dilutions:
Immunohistochemistry: Frozen sections
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Mab	IgG1	6D348	Highly Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Human	Mouse

Concentration:

~1mg/ml

Immunogen:

Recombinant human TRAIL-R4 (DcR2).

Purity:

95% (SDS-PAGE)

Form

Supplied as a liquid in PBS, 0.05% sodium azide.

Specificity:

Recognizes human TRAIL-R4. Does not cross react with human TRAIL-R1, -R2 or -R3.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. B. Washburn, et al.; J. Immunol. 170: 1814 (2003) 2. P. Secchiero, et al.; Blood 103: 517 (2004) 3. T.M. Ganten, et al.; Cell Death Differ. 11 Suppl 1, S86 (2004) 4. T. Wachter, et al.; J. Biol. Chem. 279: 52824 (2004)