Technical Data
D2675-02D
Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA)
|
Technical Data |
|
D2675-02D |
Deleted in Azoospermia-Like (DAZL, DAZL1, DAZ Homolog, DAZH, DAZ-like Autosomal, DAZLA, MGC26406, SPGY-like-autosomal, SPGYLA) |
|
|
Description: The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 1:5000 Immunohistochemistry (Formalin fixed paraffin embedded): 1:100 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
|
|||||||||||
|
||||||||||||
|
||||||||||||
|
||||||||||||