Technical Data
Desipramine (Norpramin®, Pertofrane®) (HRP)
Biochemicals Storage: -20°CShipping: Blue Ice
Desipramine is an active metabolite of imipramine and has been found to be useful in the treatment of neuropathic pain. It may also be used to treat symptoms of cocaine withdrawal. Desipramine is a tricyclic antidepressant (TCA). Tricyclic antidepressants contain a characteristic three ringed nucleus structure. They act primarily as serotonin­norepinephrine reuptake inhibitors. Tricyclic antidepressants are mainly used as antidepressants, but have also been for the treatment of anxiety disorders and attention hyperactivity disorder and as an adjunct to certain analgesics to treat chronic pain. In many treatments they have been replaced by other compounds with fewer side­effects.

Tricyclic antidepressants are not considered addictive and have a low abuse potential, but suddenly discontinuing treatment may results in discontinuation syndrome and overdose is a main cause of death from prescription drugs. They have significant cardiovascular and neurological toxicity. Monitoring of TCA levels can help determine toxicity, monitor compliance and establish individual target concentrations.

Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA, Competive: 1:80
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Labeled with horseradish peroxidase (HRP). Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates
Form: Supplied as a lquid. Labeled with HRP.
Purity: Purified

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
General References::
1. Haddad, L.M., (1992), "Managing tricyclic antidepressant overdose", Am. Fam. Physician, 46(1): 153-159. 2. Pimentel, L., et al (1994), "Cyclic antidepressant overdoses. A review", Emerg. Med. Clin. North. Am., 12(2): 533-547.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.