Technical Data
Ivermectin B1b (Dihydroavermectin B1b, 22, 23-Dihydroavermectin B1b )
Biochemicals Storage: 4C/-20CShipping: Blue Ice
Ivermectin B1b is the minor component (>20%) of the commercial anthelmintic, ivermectin. Members of the avermectin/milbemycin anthelmintic class exert their anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. The avermectin/milbemycins are also potent insecticides. In vitro tests have found the B1b (25-iso-propyl) analogue to be slightly more potent than the 25-sec-butyl (B1a) analogue as an inhibitor of nematode larval development and paralysis and also a more sensitive probe for ivermectin resistance.

Soluble in ethanol, methanol, DMF or DMSO.

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Source: Streptomyces sp.
Purity: >95% by HPLC
Form: White solid

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Ivermectin, a new broad-spectrum antiparasitic agent. Chabala J.C. et al. J. Med. Chem. 1980, 23, 1134. 2. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. Wolstenholme A.J & Rogers A.T. Parasitology, 2005, 131, S85. 3. Avermectin/milbemycin resistance in trichostrongylid nematodes. Gill J.H. & Lacey E. Int J. Parasitol. 1998, 28, 863. 4. Ivermectin: a potent new antiparasitic agent. Campbell W.C. et al., Science, 1983, 221, 823.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.