Technical Data
DNA Methyltransferase 2 (DMNT2, DNMT2, DNA Methyltransferase Homolog HsaIIP, M.HsaIIP, PuMet, RNMT1, tRNA Aspartic Acid Methyltransferase 1, TRDMT1)
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. Dnmt2 contains all the sequence motifs diagnostic of DNA (cytosine-5)-methyltransferases but appears to lack the large N-terminal regulatory domain common to other eukaryotic methyltransferases.

Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 1-3ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
MabIgG102B1259.2Affinity Purified
50ug-20CBlue IceMouseMouse
Synthetic peptide corresponding to mouse Dnmt2 (KLH).
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
Recognizes mouse TRDMT1. Species sequence homology: human
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.