Technical Data
D8072-60
17-DMAG Hydrochloride (17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride) (17-DMAG Hydrochloride, NSC-707545, Alvespimycin)
250mg
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Technical Data |
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D8072-60 |
17-DMAG Hydrochloride (17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin Hydrochloride) (17-DMAG Hydrochloride, NSC-707545, Alvespimycin) |
250mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Solubility: Soluble in DMSO; soluble up to about 2mg/ml in water. Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. CAS Number: 150270-08-9 Molecular Formula: C32H48N4O8•HCl Molecular Weight: 653.21 |
Purity: ~99% Form: Supplied as a purple powder. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Egorin, M.J., et al. "Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats." Cancer Chemother. Pharmacol. 49:7-19 (2002). 2. Tian, Z.Q., et al. "Synthesis and biological activities of novel 17-aminogeldanamycin derivatives." Bioorg. Med. Chem. 12:5317-5329 (2004). 3. Kaur, G, et al. "Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator." Clin. Cancer Res. 10:4813-4821 (2004). 4. Bull, E.E., et al. "Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin." Clin. Cancer Res. 10:8077-8084 (2004). 5. Hollingshead, M., et al. "In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative." Cancer Chemother. Pharmacol. 56:115-125 (2005).
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