Technical Data
D8073-02A
DMAP1 (DNA Methyltransferase 1-Associated Protein 1, DNMAP1, DNMTAP1, DNMT1-Associated Protein 1, MAT1-Mediated Transcriptional Repressor)
Description:
DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X-chromosome inactivation. DNA methyltransferase 1 associated protein (DMAP1) has been shown to interact directly with the N-terminus of DNA Methyltransferase 1 (Dnmt1) throughout DNA replication during S phase. DMAP1 has also been identified as a critical gene product in myotonic dystrophy.

Applications:
Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Western Blotting: 1:1000-1:2000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabAffinity Purified
SizeStorageShippingSourceHost
100ug-20°CBlue IceHumanGoat
Concentration:
As reported
Immunogen:
A 25 amino acid synthetic peptide, which represented a portion of human DNA methyltransferase 1-associated protein 1 encoded in part by exons 2 and 3 (LocusLink ID 55929).
Purity:
Purified by immunoaffinity chromatography.
Form
As reported
Specificity:
This antibody is specific for human DMAP1. Species Crossreactivity: Recognizes human. Other species have not been tested. Reactivity with mouse is likely owing to 25/25 identical residues between mouse DMAP1 and the peptide used for this production. May react with Zebrafish (22/25 identical residues).
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.