Technical Data
DMAP1 (DNA Methyltransferase 1-Associated Protein 1, DNMAP1, DNMTAP1, DNMT1-Associated Protein 1, MAT1-Mediated Transcriptional Repressor)
DNA methyltransferases methylate the 5-position of cytosine in the context of CpG dinucleotides. DNA methylation is crucial for normal embryonic development, imprinting, and X-chromosome inactivation. DNA methyltransferase 1 associated protein (DMAP1) has been shown to interact directly with the N-terminus of DNA Methyltransferase 1 (Dnmt1) throughout DNA replication during S phase. DMAP1 has also been identified as a critical gene product in myotonic dystrophy.

Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Western Blotting: 1:1000-1:2000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabAffinity Purified
100ug-20CBlue IceHumanGoat
As reported
A 32 amino acid synthetic peptide, which represented a portion of human DNA methyltransferase 1-associated protein 1 encoded within exon 8 (LocusLink ID 55929).
Purified by immunoaffinity chromatography.
As reported
This antibody is specific for human DMAP1. Species Crossreactivity: Recognizes human. Other species have not been tested. Probablility of reactivity with mouse is poor owing to divergence between mouse DMAP1 and the peptide used for this production.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.