Technical Data
D9099-43
Doxorubicin (Adriamycin, 14-Hydroxydaunomycin, Adriacin, Adriblastin, Caelyx, Dox, Doxil, Farmiblastina, FI 106, K 1039, KW 125, NSC 123127)
25mg
Biochemicals Storage: -20CShipping: Blue Ice
Doxorubicin is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumor agent for the treatment of a wide range of cancers. Doxorubicin has also been reported to exhibit anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.

Apperance:
As Reported

Solubility:
As Reported

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Soluble in ethanol, methanol, DMSO and DMF. Poor water solubility. Aliquot to avoid repeated freezing and thawing. Store at -20C. Light Sensitive.

CAS Number:
23214-92-8

Molecular Formula:
C27H29NO11

Molecular Weight:
543.5
Source: Streptomyces peucetius MST-AS5775
Purity: ~99% (HPLC)
Form: As Reported

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
US Biological application reference: Abouzeid, A.H., et al., (2013) J Drug Target., doi:10.3109/1061186X.2013.840639. 1. Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic. Arcamone F. et al., Tet. Letters 1969, 13, 1007. 2. Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Fornari F.L. et al., Mol. Pharmacology 1994, 45, 649. 3. Effect of Adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Momarier R. et al., Cancer Research 1976, 36, 2891.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.