Technical Data
D9099-43
Doxorubicin (Adriamycin, 14-Hydroxydaunomycin, Adriacin, Adriblastin, Caelyx, Dox, Doxil, Farmiblastina, FI 106, K 1039, KW 125, NSC 123127)
25mg
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Technical Data |
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D9099-43 |
Doxorubicin (Adriamycin, 14-Hydroxydaunomycin, Adriacin, Adriblastin, Caelyx, Dox, Doxil, Farmiblastina, FI 106, K 1039, KW 125, NSC 123127) |
25mg |
| Biochemicals | Storage: -20°CShipping: Blue Ice |
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Doxorubicin is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for human therapeutic use as an antitumor agent for the treatment of a wide range of cancers. Doxorubicin has also been reported to exhibit anti-HIV and antibacterial activity. The mode of action of doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis. Apperance: Orange red solid Solubility: Soluble in DMSO, dichloromethane and ethyl acetate. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Soluble in water, methanol, DMSO, DMF with moderate ethanol solubility. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Light Sensitive. CAS Number: 23214-92-8 Molecular Formula: C27H29NO11 Molecular Weight: 543.5 |
Source: Streptomyces peucetius MST-AS5775 Purity: ~99% Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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1. Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic. Arcamone F. et al., Tet. Letters 1969, 13, 1007. 2. Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Fornari F.L. et al., Mol. Pharmacology 1994, 45, 649. 3. Effect of Adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Momarier R. et al., Cancer Research 1976, 36, 2891.
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