Technical Data
a-Dystroglycan (Alpha-Dystroglycan, Alpha-DG, 156DAG, A3a, AGRNR, Cranin, Dystrophin-associated Glycoprotein 1, DAG1, DAG)
Cranin is expressed in brain and many other tissues, it binds laminin with high affinity in a calcium dependent manner. It appears to be important in maintaining normal muscle integrity. Loss of cranin from the muscle surface may be one of the primary events leading to muscle injury in congenital muscular dystrophies, it may also play a role in the cognitive deficits often seen in such conditions

Suitable for use in ELISA and Immunohistochemistry. Not suitable for Western Blot. Other applications not tested.

Recommended Dilutions:
Immunohistochemistry (Frozen): 1:1-1:50
Optimal dilutions to be determined by the researcher.

Recommended Positive Control Tissue:
Neurons, atsrocytes, smooth muscle, fibroblasts or epithelial cell lines.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
100ul-20CBlue IceHumanMouse
Not Determined
A synthetic peptide corresponding to aa 572-604 of human cranin (dystroglycan).
Supplied as a liquid. No preservatives added.
Recognizes an extracellular region close to the C terminal end of the alpha subunit of human cranin, also known as dystroglycan. Species crossreactivity: mouse, Xenopus, chicken, sheep and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.