Technical Data
ELP1 (Elongator Complex Protein 1, IKAP, IkappaB Kinase Complex-associated Protein, IKK Complex-associated Protein, p150, IKBKAP, ELP1)
The transcription factor NF-kappaB coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappaB is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes These large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for three different kinases involved in pro-inflammatory cytokine signaling.

Suitable for use in Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: 1:500-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
PabIgGAffinity Purified
100ug-20CBlue IceHumanRabbit
Synthetic peptide corresponding to the C terminus of IKAP.
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, 0.02% sodium azide.
Recognizes human IKAP.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Cohen L., Henzel W. J, and Baeuerle P.A. Nature. 1998 Sep 17;395(6699):225.