Technical Data
E2249-79S
ELP1 (Elongator Complex Protein 1, IKAP, IkappaB Kinase Complex-associated Protein, IKK Complex-associated Protein, p150, IKBKAP, ELP1)
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Technical Data |
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E2249-79S |
ELP1 (Elongator Complex Protein 1, IKAP, IkappaB Kinase Complex-associated Protein, IKK Complex-associated Protein, p150, IKBKAP, ELP1) |
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Description: The transcription factor NF-kappaB coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappaB is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes These large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for three different kinases involved in pro-inflammatory cytokine signaling. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1:500-1:1000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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