Technical Data
Elongator Protein 1 (ELP1, Inhibitor Of Kappa Light Polypeptide Gene Enhancer In B Cells, Kinase Complex-associated Protein, IKBKAP, DYS, ELP1, FD, FLJ12497, IKAP, IKI3, P150, TOT1, DKFZP781H1425)
Its function is not clear, but it has been demonstrated that the human Elongator facilitates transcription by RNA polymerase II in a chromatin- and acetyl-CoA-dependent manner. IKBKAP. IKBKAP was originally described as a scaffold protein of the IKK complex involved in NF-kB activation, but this role has since been disputed. IKBKAP is a component of the RNA polymerase II elongator complex which has histone acetyltransferase activity and is involved in transcriptional elongation. Gene defects are a cause of familial dysautonomia, also known as Riley-Day syndrome. Affected individuals show a variety of symptoms such as decreased sensitivity to pain and temperature, cardiovascular instability, pneumonia and gastrointestinal dysfunction.

Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
MabIgG2a9F621Affinity Purified
150ug-20CBlue IceHumanMouse
Elongator complex (130kD)
Purified by Protein G affinity chromatography.
Supplied as a liquid in PBS, pH 7.2.
Recognizes human ELP1
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Kim, J-H. (2002) Proc. Natl. Acad. Sci. USA 99,1241 " 1246; Hawkes, N. et al. (2002) J. Biol. Chem. 277, 3047 " 3052.