Technical Data
E3098-27
Endothelin 1
Description:
Endothelins (ET) show potent constrictor activity in vascular and non-vascular smooth muscle. This family of 21-amino acid peptides exists in at least three isoforms, ET-1, ET-2, and ET-3, and is produced in endothelial and epithelial cells. ET's can mediate biological effects in cells and tissues, and have been shown to bind to an ET receptor in the lung, kidney, heart and liver.

Applications: Suitable for use in RIA Other applications not tested.

Recommended Dilution: Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20C or colder. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
MabIgG11.B.758Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceHumanMouse
Concentration:
Immunogen:
Human Endothelin-1
Purity:
Purified
Form
Supplied as a liquid in PBS, pH 7.4. No preservative added.
Specificity:
Crossreactivities determined by competitive RIA: Concentrations (pg/tube) to give 50% B/Bo: Endothelin-1 (human) 1x10e1, Endothelin-2 (human) 4x10e0, Endothelin-3 (human) 1x10e3, Big Endothelin (human) 4x10e0, Endothelin C-terminal hexapeptide <10e5, Atrial natriuretic peptide (human) <10e5, Sarafotoxin S6c 2x10e4
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.