Technical Data
E3222-29
Enniatin B1 (2-(N-Methyl-L-isoleucine) Enniatin B)
1mg
Biochemicals Storage: 4CShipping: Blue Ice
Enniatins are a family of depsipeptides produced several Fusarium species. The enniatins have been shown to act as ionophores. More recently their effects on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumor action have received more focus. Enniatin B1 is one of four major analogues of the enniatin complex and has not previously been available for investigation.

Source:
Enniatin B1

Molecular Weight:
~653.9

Solubility:
Soluble in ethanol, methanol, DMF or DMSO.

Storage and Stability:
Lyophilized powder may be stored at -20C. Stable for 12 months at -20C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

CAS Number:
19914-20-6

Molecular Formula:
C34H59N3O9

Molecular Weight:
653.9
Source: Fusarium sp. MST-FP1765
Purity: 95% by HPLC
Form: Supplied as a white powder.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. Toxicity and Hazards:All products should be handled by qualified personnel only, trained in laboratory procedures.
1. Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann E. et al., Experientia 3: 202 (1947). 2. "Sandwich" complexation in cyclopeptides and its implications in membrane processes. Ivanov, V.T., Ann. N.Y. Acad. Sci. 264, 221 (1975). 3. Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish, K.A., et al., Pept. Res. 3: 233 (1990). 4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga, K., et al., Biochem. Biophys. Res. Commun. 328: 1119 (2005). 5. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber, R., et al., Chem. Res. Toxicol. 20: 465 (2007).

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.