Technical Data
E3310-01A
Enterovirus
Description:
The enteroviruses are a genus of (+)ssRNA viruses associated with several human and mammalian diseases. Historically the most significant has been the Poliovirus. Other types are coxsackie and echovirus. Enterovirus are the most common cause of aseptic meningitis and can cause serious disease especially in infants and the immunocompromised. Human enteroviruses (family Picornaviridae) infect millions of people worldwide each year, resulting in a wide range of clinical outcomes ranging from unapparent infection to mild respiratory illness (common cold), hand, foot and mouth disease, acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis. In the United States, enteroviruses are responsible for 30,000 to 50,000 meningitis hospitalizations per year as a result of 30 million to 50 million infections. Serologic studies have distinguished 66 human enterovirus serotypes on the basis of an antibody neutralization test, and additional antigenic variants have been defined within several of the serotypes on the basis of reduced or nonreciprocal cross-neutralization between prototype and variant strains. On the basis of their pathogenesis in humans and experimental animals, the enteroviruses were originally classified into four groups, polioviruses, coxsackie A viruses (CA), coxsackie B viruses (CB), and echoviruses, but it was quickly realized that there were significant overlaps in the biological properties of viruses in the different groups. The more recently isolated enteroviruses have been named with a system of consecutive numbers: EV68, EV69, EV70, and EV71. There "are 62 non-polio enteroviruses that can cause disease in humans: 23 Coxsackie A viruses, 6 Coxsackie B viruses, 28 echoviruses, and 5 other enteroviruses.

Applications:
Suitable for use in Immunofluorescence and ELISA. Other applications not tested.
Recommended Dilution:
Immunofluorescence: 1:10-1:50
ELISA: 1:20-1:200
Optimal dilutions to be determined by the researcher.
Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG310D3Affinity Purified
SizeStorageShippingSourceHost
100ug4C Do Not FreezeBlue IceMouse
Concentration:
~0.1mg/ml
Immunogen:
Enterovirus
Purity:
Purified by Protein A affinity chromatography.
Form
Supplied as a liquid in 0.01M PBS, pH 7.2, 0.1% sodium azide. No stabilizing proteins added.
Specificity:
Recognizes most Enterovirus. Negative vs. ECHO 34, EV70, and EV71.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.