Technical Data
E3310-05
Enterovirus 70
Description:
The enteroviruses are a genus of (+)ssRNA viruses associated with several human and mammalian diseases. Historically the most significant has been the Poliovirus. Other types are coxsackie and echovirus. Enterovirus are the most common cause of aseptic meningitis and can cause serious disease especially in infants and the immunocompromised. Human enteroviruses (family Picornaviridae) infect millions of people worldwide each year, resulting in a wide range of clinical outcomes ranging from unapparent infection to mild respiratory illness (common cold), hand, foot and mouth disease, acute hemorrhagic conjunctivitis, aseptic meningitis, myocarditis, severe neonatal sepsis-like disease, and acute flaccid paralysis. In the United States, enteroviruses are responsible for 30,000 to 50,000 meningitis hospitalizations per year as a result of 30 million to 50 million infections. Serologic studies have distinguished 66 human enterovirus serotypes on the basis of an antibody neutralization test, and additional antigenic variants have been defined within several of the serotypes on the basis of reduced or nonreciprocal cross- neutralization between prototype and variant strains. On the basis of their pathogenesis in humans and experimental animals, the enteroviruses were originally classified into four groups, polioviruses, coxsackie A viruses (CA), coxsackie B viruses (CB), and echoviruses, but it was quickly realized that there were significant overlaps in the biological properties of viruses in the different groups. The more recently isolated enteroviruses have been named with a system of consecutive numbers: EV68, EV69, EV70, and EV71.

Applications:
Suitable for use in Immunofluorescence and Neutralization. Other applications not tested.

Recommended Dilutions:
Immunofluorescence: 1:250.
Neutralization: <1:16 (Titer)
Optimal dilution determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
MabIgG2Q1931Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouse
Concentration:
~1mg/ml
Immunogen:
Enterovirus 70 strain J670-71
Purity:
Purified
Form
Supplied as a liquid in PBS, pH 7.6, 0.1% sodium azide.
Specificity:
Recognizes and neutralizes all Enterovirus 70 strains. Binds to the P1 protein of Enterovirus 70.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.