		Technical Data
E3440-25A	Epstein Barr Virus, Early Antigen, Restricted p17, Bc12 (EA) (EBV)

Description:
The Early Restricted protein (EA-Restricted p17) of Epstein-Bar Virus is encoded by the viral BHFR1 gene. EA-Restricted p17 is a 17kD protein (p17) with protein kinase activity. EA-Restricted p17 is a functional homologue of the anti-apoptotic oncoprotein bcl-2, which is expressed during the switch from latency to lytic replication and may be involved in proliferation of EBV infected cells. However, EA-Restricted p17 does not appear to be essential for virus replication or transformation of B cells in vitro.

Applications:
Suitable for use in ELISA, Western Blot, Immunofluorescence and Immunoprecipitation. Other applications not tested.

Recommended Dilutions:
Optimal dilutions to be determined by researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Mab	IgG2a	2Q1912	Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice		Mouse

Concentration:

~1mg/ml

Immunogen:

Epstein Barr Virus, Early Antigen

Purity:

Purified

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.

Specificity:

Recognizes Epstein Barr Virus, Early Antigen, Restricted p17, Bc12 homologue at ~17kD. Species Crossreactivity: human

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

1. Nicholls, J. et al., (2001) J Med Virol 65:105-113. 2. Meseda, C. et al., (2000) J Gen Virol 81:1801-1805. 3. Dawson, C. et al., (1998) J Virol 72:9016-9024. 4. Pearson, G. et al., (1987) Virol 160:151-161.