Technical Data
Erythropoietin, alpha, Recombinant, Human (Liquid) (EPO, EPO-a, EPO-alpha, Epoetin, EP, MGC138142)
Molecular Biology Storage: -70CShipping: Dry Ice
Erythropoietin, ~34-36kD, normally produced in the kidney and liver, is the principle hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Indicated for treatment of neutropenia or anemia secondary to ZDV- or Ganciclovir-induced bone marrow suppression (most effective in patients with endogenous EPO levels < 500 IU/ml).

Dimers and Aggregates:
1% as determined by silver stained SDS-PAGE gel analysis.

Biological Activity:
Fully biologically active when compared to standard.

Specific Activity
(Normocythaemic mice): ~120,000 IU/mg.

Storage and Stability:
Aliquot to avoid repeated freezing and thawing and freeze at -70C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.

Molecular Weight:
Source: Recombinant Human in Chinese hamster ovary (CHO) cells
Purity: Chromatographically purified. 98% by RP-HPLC, Anion-exchange FPLC. Analyzed by reducing and non-reducing SDS-PAGE, Silver Stained. Endotoxin: 0.1ng/ug (IEU/ug)
Concentration: ~0.1mg/ml
Form: Supplied as a liquid in sodium citrate, sodium chloride, citric acid buffer.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Ford PA, Ford JM, (2004) Transfusion Dec;44(12 Suppl):15S-25S. 2. Wei X, Swanson SJ, (2004) J Immunol Methods Oct;293(1-2):115-26. 3. Godin M, (2004) Soins Sep;(688 Suppl):5. 4. Cervantes F, Alvarez-Larran A, Sureda A, (2004) Br J Haematol Nov 127(4):399-403. 5. Mesjasz J, Wiecek A, Mazur W, (2004) Pol Merkuriusz Lek Apr 16(94):362-7. 6. Bergstrom S, Ahlgren J, (2004) Lakartidningen Oct 7;101(41):3160-1.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.