Technical Data
F0019-58V7B
Fanconi anemia C (FANCC, FA3, FAC, FACC, bA80I15.1, FLJ14675)
Description:
The members of the Fanconi anemia complementation group do not share sequence similarity but are related by their assembly into a common nuclear protein complex.

FANCC is involved in DNA repair and maybe involved in maintenance of normal chromosome stability and inter-strand DNA cross link repair.

Mutations in the FANCC gene are a cause of Fanconi anemia (FA), a genetically heterogeneous recessive disorder characterized by progressive pancytopenia, susceptibly to malignancies, cytogenetic instability, hypersensitivity to DNA damaging agents and defective DNA repair. FANC complexes are not found in individuals with FA.

Applications:
Suitable for use in ELISA, Immunohistochemistry (paraffin), and Western Blot. Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 2.5ug/ml
ELISA: 1:20,000-1:80,000
Western Blot: 1:1000-1:3000
Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections.
Optimal dilutions to be determined by the researcher.

Positive Control: Human brain (cortex)

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
50ugBlue IceHumanRabbit
Concentration:
~1mg/ml
Immunogen:
Synthetic peptide corresponding to aa sequence 96-112 of human FANCC.
Purity:
Purified by immunoaffinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
Specificity:
Recognizes human FANCC. Species Crossreactivity: chimpanzee.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.