Technical Data
Fanconi anemia F (FANCF, FAF, MGC126856, Protein FACF)
Research indicates that FANCF is involved in DNA repair, either with post-replication repair or a cell cycle checkpoint function. FANCF has also been implicated in inter-strand DNA cross-link repair and in the maintenance of normal chromosome stability.

Defects in FANCF are a cause of Fanconi anemia (FA). FA is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopaenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. At the cellular level, it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage), and defective DNA repair.

Suitable for use in ELISA and Immunohistochemistry (paraffin). Other applications not tested.

Recommended Dilution:
Immunohistochemistry (paraffin): 2.5ug/ml
ELISA: 1:15,000-1:60,000
Requires antigen retrieval using heat treatment prior to staining of paraffin sections.
Optimal dilutions to be determined by the researcher.

Positive Control: Human kidney

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabIgGAffinity Purified
50ugBlue IceHumanRabbit
A synthetic peptide corresponding to an internal aa sequence of human FANCF.
Purified by immunoaffinity chromatography.
Supplied as a liquid in PBS, pH 7.2, 0.01% sodium azide.
Recognizes human FANCF. Species Crossreactivity: chimpanzee.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.