Technical Data
F4150-11D
Fkbp1a (Peptidyl-prolyl Cis-trans Isomerase FKBP1A, PPIase FKBP1A, 12kD FK506-binding Protein, 12kD FKBP, FKBP-12, Calstabin-1, FK506-binding Protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase, Fkbp1)
Description:
FKBP12 is a member of the family of soluble receptors capable of binding to one of two major immunosuppressant agents. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.

Applications:
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-4ug/ml
Immunoprecipitation: 2-10ug/ml
Immunohistochemistry: 2-10ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGAffinity Purified
SizeStorageShippingSourceHost
100ug-20CBlue IceMouseRabbit
Concentration:
~0.5mg/ml
Immunogen:
Synthetic peptide corresponding to aa10 from mouse FKBP12.
Purity:
Purified by affinity chromatography.
Form
Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.
Specificity:
Recognizes mouse FKBP12 at ~12kD. Species Crossreactivity: Human and rat.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.