		Technical Data
F4150-11D	Fkbp1a (Peptidyl-prolyl Cis-trans Isomerase FKBP1A, PPIase FKBP1A, 12kD FK506-binding Protein, 12kD FKBP, FKBP-12, Calstabin-1, FK506-binding Protein 1A, FKBP-1A, Immunophilin FKBP12, Rotamase, Fkbp1)

Description:
FKBP12 is a member of the family of soluble receptors capable of binding to one of two major immunosuppressant agents. FKBP12 also plays a role in intracellular calcium regulation by associating with three types of calcium release channel complexes, cardiac and skeletal ryanodine receptors and the inositol 1,4,5-trisphosphate receptor. In interactions with members of the TGF beta family type I receptors, FKBP12 has been shown to exert an inhibitory effect on the signaling pathway.

Applications:
Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.

Recommended Dilution:
Western Blot: 0.5-4ug/ml
Immunoprecipitation: 2-10ug/ml
Immunohistochemistry: 2-10ug/ml
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Type	Isotype	Clone	Grade
Pab	IgG		Affinity Purified

Size		Storage	Shipping	Source	Host
100ug		-20°C	Blue Ice	Mouse	Rabbit

Concentration:

~0.5mg/ml

Immunogen:

Synthetic peptide corresponding to aa10 from mouse FKBP12.

Purity:

Purified by affinity chromatography.

Form

Supplied as a liquid in PBS, pH 7.2, 0.5% BSA, 0.01% thimerosal, 30% glycerol.

Specificity:

Recognizes mouse FKBP12 at ~12kD. Species Crossreactivity: Human and rat.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.