Technical Data
Fractalkine, Recombinant, Human (FKN, A-152E5.2, ABCD-3, Chemokine (C-X3-C Motif) Ligand 1, C-X3-C Motif Chemokine 1, C3Xkine, CXC3, CXC3C, CX3CL1, Neurotactin, NTN, NTT, Small Inducible Cytokine D1, SCYD1)
Molecular Biology Storage: -20°CShipping: Blue Ice
AHP453B is specific for human fractalkine, otherwise known as CX3CL1, a 397aa CX3C chemokine which signals through the CX3CR1 receptor and is expressed by various tissues including the brain, testis, lung, heart, kidney, colon and skeletal muscle.

Adhesion of fractalkine to the CX3CR1 receptor triggers the chemotaxis and adhesion of leukocytes, including T cells, monocytes and NK cells and studies have suggested that fractalkine is involved in the regulation of brain microglia during neuroinflammatory processes (1) and may play a role in dendritic cell–mediated host defense against invading pathogens such as Legionella pneumophila (2).

Recombinant corresponding to human Fractalkine.

Suitable for use in Functional Assays. Other applications not tested.

Recommended Dilution:
Optimal dilutions to be determined by the researcher.

Storage and Stability:

Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot and store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source: Human
Purity: Purified by immunoaffinity chromatography.
Form: Supplied as a lyophilized powder in PBS. Preservative free. Reconstitute with sterile PBS to 1mg/ml containing 0.1% BSA.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Sunnemark, D. et al. (2005) CX3CL1 (fractalkine) and CX3CR1 expression in myelin oligodendrocyte glycoprotein-induced experimental immune encephalomyelitis: kinetics and cellular origin. J. Neuroinflamm. 2: 17. 2. Kikuchi, T. et al. (2005) Involvement of Fractalkine/CX3CL1 expression by dendritic cells in the enhancement of host immunity against Legionella pneumophila. Infect. Immun. 73: 5350-5357.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.