Technical Data
Galanin Receptor 3 (GALR3)
GalR3 is a Galanin Receptor that is similar, but distinct from the other galanin receptors, and it mediates the effects of the galanin peptide in a wide variety of tissues. Like GalR1, the signaling mechanism is predominantly through inhibition of adenylate cyclase. GalR3 has been reported in brain, testis, adrenal gland, and pancreas. An EST has been isolated from an ovarian thecoma fibroma library.

Gene Symbol:

Suitable for use in ELISA and Western Blot. Other applications not tested.

Recommended Dilution:
Western Blot: ~37kD band observed in human skin and human testes lysates.
Optimal dilutions to be determined by the researcher.

Positive Control:
Human Skin Protein antigen standard for GALR3 (NM_003614) (transient overexpression lysate)

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20C. Aliquots are stable for at least 12 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
PabAffinity Purified
100ug-20CBlue IceHumanGoat
Synthetic peptide: C-QGPEPREGPVHGGE, representing the C Terminus of the human protein according to NP_003605.1.
Purified by immunoaffinity chromatography.
Supplied as a liquid in Tris-saline, pH 7.2. 0.5% BSA, 0.02% sodium azide.
Species Crossreactivity: Human. Other species not tested.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
Swanson CJ, Blackburn TP, Zhang X, Zheng K, Xu ZQ, Hokfelt T, Wolinsky TD, Konkel MJ, Chen H, Zhong H, Walker MW, Craig DA, Gerald CP, Branchek TA. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17489-94. Epub 2005 Nov 15. PMID: 16287967 Other PMIDs: 11867941