Technical Data
Gentisic Acid, Sodium Salt (Sodium Gentisate)
Biochemicals Storage: RTShipping: RT
Gentisic acid (2,5-Dihydroxybenzoic acid; 5-hydroxysalicylic acid) is chemically related to salicylate and aspirin (acetylsalicylate) and shares with the latter agent analgesic and anti-inflammatory properties. Gentisic acid is an aromatic carboxylic acid used as a sample matrix in Matrix-assisted laser desorption/ionization Mass spectrometry. As a hydroquinone, it is readily oxidized and is used as an antioxidant excipient in some pharmaceutical preparations.

In vitro stabilization of low-tin bone-imaging agents has previously been achieved with ascorbic acid. Gentisic acid is shown to be an equally effective antioxidant for the (1-hydroxyethylidene) diphosphonate (HEDP) and hydroxymethylenediphosphonate (HMDP) skeletal agents. In vitro studies show less than 2% free sodium [99mTc] pertechnetate at 24 hr with the gentisic acid stabilizer. Studies in guinea pigs at 3 and 24 hr—whether with C-14- or H-3-labeled gentisic acid as stabilizer—show no alteration in the biodistribution of either skeletal imaging agent by the addition of the gentisic acid.

Gentisic acid is a safe and effective stabilizer, and clinical studies have shown bioequivalency with ascorbic acid. Gentisic acid has been shown to be one of the most commenly occurring aromatic acids of green plants.

Solubility (50mg/ml, H2O):
Amber, clear, complete

pH (1%):

Loss of Drying:

Residue on Ignition:


Related Substances:

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Molecular Formula:

Molecular Weight:
Purity: 99%
Form: Supplied as a white to tan crystalline powder.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. The Journal of Nuclear Medicine Vol. 21 No. 4 366-370, “Gentisic Acid: A New Stabilizer for Low Tin Skeletal Imaging Agents: Concise Communication”, Andrew J. Tofe, John A. Bevan, Mahdi B. Fawzi, Marion D. Francis, Edward B. Silberstein, George A. Alexander, Donald E. Gunderson and Karen Blair 2. Braz J Med Biol Res. 2001 Mar;34(3):381-8, “The mechanism of gentisic acid-induced relaxation of the guinea pig isolated trachea: the role of potassium channels and vasoactive intestinal peptide receptors.”, Cunha JF, Campestrini FD, Calixto JB, Scremin A, Paulino N.
2. Oxidative coupling reaction of arbutin and gentisate catalyzed by horseradish peroxidase T. Kiso, et al., J. Mol. Catal., B Enzym. 45, 50-56, (2007)

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.