Technical Data
Gilvocarcin V (Anandimycin A, Toromycin B, Antibiotic 1072B)
Biochemicals Storage: -20C, protect from lightShipping: Blue Ice
Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research on the gilvocarcins suggests that they act as photoactiviated crosslinkers of DNA to histones.

Purity: > 95% by HPLC

Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.

Related to: Chrysomycin A, Chrysomycin B, Gilvocarcin M, O-Deacetyl-ravidomycin

CAS Number:

Molecular Formula:

Molecular Weight:
Source: Streptomyces sp.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated
gilvocarcin V in human fibroblasts. Matsumoto A. & Hanawalt P.C. Cancer Res. 2000, 60, 3921.
2. Photoactivated gilvocarcin V induces DNA-protein crosslinking in genes for human ribosomal RNA and
dihydrofolate reductase. Matsumoto A. et al. Photochem. Photobiol. 1994, 60, 225.
3. Activation of antitumor agent gilvocarcins by visible light. Elespuru R.K. & Gonda S.K. Science 1984,
223, 69.
4. Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. Balitz D.M. et al. J. Antibiot.
1981, 34, 1544-1555.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.