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Technical Data |
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G3900-09A |
GLUT 1 (Glucose Transporter 1, Glucose Transporter Type 1 Erythrocyte/brain, GLUT1, GLUT-1, GLUT, GLUT1DS, DYT17, DYT18, HepG2 Glucose Transporter, MGC141895, MGC141896, PED, Solute Carrier Family 2 Facilitated Glucose Transporter Member 1, SLC2A1) |
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Description: GLUT1, a prototype member of GLUT super family, is a membrane-associated erythrocyte glucose transport protein. It is a major glucose transporter in the mammalian blood-brain barrier, and also mediates glucose transport in endothelial cells of the vasculature, adipose tissue and cardiac muscle. It consists of characteristic 12 transmembrane helices and is present at high levels in primate erythrocytes and brain endothelial cells. GLUT1 also transports vitamin C into the brain. Mutations in GLUT1 result in GLUT1 deficiency syndrome across the blood-brain barrier. GLUT1 has been shown to be overexpressed in many cancer types suggesting a possible diagnostic marker. Applications: Suitable for use in Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry (paraffin): 1:50-1:100 Optimal dilutions to be determined by the researcher. Positive Control: Breast carcinoma Cellular Localization: Cytoplasmic Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. |
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