Technical Data
G8989-45B
Growth and Differentiation Factor 5, 382-501aa, Recombinant, Human (GDF5)
100ug
Molecular Biology Storage: -20CShipping: Blue Ice
Growth differentiation factor 5(GDF-5) is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in chondrogenesis and chondrocyte metabolism, tendon and ligament tissue formation, and bone repair. It also increases the survival of neurones that respond to a neurotransmitter called dopamine, and is a potential therapeutic molecule associated with Parkinson's disease.

GDF-5, fused to His-tag at N-terminus, was expressed as insoluble protein aggregate in E. coli.

Amino Acid Sequence:
MGSSHHHHHH SSGLVPRGSH MAPLATRQGK RPSKNLKARC SRKALHVNFK DMGWDDWIIA PLEYEAFHCE GLCEFPLRSH LEPTNHAVIQ TLMNSMDPES TPPTCCVPTR LSPISILFID SANNVVYKQY EDMVVESCGC R

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
15.8kD
Source: E. coli
Purity: 95% (SDS-PAGE). Endotoxin: 1EU/ug (LAL)
Concentration: ~0.5mg/ml
Form: Supplied as a liquid in 10mM sodium citrate, pH 3.5, 10% glycerol


Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1. Feng G., et al. (2008). Growth Factor. 26(3):132-42 2. Sullivan AM., et al. (2005). J Anat. 207(3):219-26.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.