Technical Data
G8989-50A
GDF15, Recombinant, Human, His-Tag, aa195-308 (Growth Differentiation Factor 15, PDF, MIC1, PLAB, MIC-1, NAG-1, PTGFB, GDF-15, PTGF-beta, Prostate Differentiation Factor, NSAID (Nonsteroidal Inflammatory Drug)-activated Protein 1)
100ug
Growth Factors, Cytokines Storage: -20CShipping: Blue Ice
Growth differentiation factor 15 (GDF-15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. This protein is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 was expressed in E. coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Source:
Recombinant corresponding to human GDF-15, his-tagged, expressed in E. coli.

AA Sequence:
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I

Storage and Stability:
May be stored at 4C for short-term only. For long-term storage, aliquot and store at -20C. Aliquots are stable for at least 6 months at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight:
16.7kD
Source: E.coli
Purity: ~95% (SDS-PAGE) Purified by immunoaffinity chromatography.
Concentration: ~0.5mg/ml
Form: Supplied as a liquid in 10mM, pH3.5, 10% glycerol.

Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
1.Paralkar V.M, et al. (1998) J Biol Chem. 273:13760-13767.
2.Hsiao E, Koniaris L., et al. (2000) Mol Cell Biol 20(10):374251.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.