Technical Data
H7023-12B
Hox B4 (Homeobox Protein B4, HOXB4, HOX-B4, Homeobox 2F, Hox 2F, HOX 2, Hox 2.6)
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Technical Data |
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H7023-12B |
Hox B4 (Homeobox Protein B4, HOXB4, HOX-B4, Homeobox 2F, Hox 2F, HOX 2, Hox 2.6) |
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Description: Homebox transcription factors (Hox) are encoded by highly conserved developmental genes that are involved embryonic and early hematopoietic development. Specifically, Homeobox B4 (HoxB4) is a transcription factor encoded by HOXB4 gene and it is involved in the developmental regulation of specific positional identities on the anterior-posterior axis of cells. Like all members of HOX family, HoXB4 is abundantly expressed in primitive hematopoietic stem cell (HSC), but then decline with lineage-specific terminal differentiation. In HSC, stem cell self-renewal activity is regulated by USF1/2 binding to HoxB4, where binding possibly favors stem cell self-renewal instead of cell differentiation. Jun-B and Fra-1 has been linked as key mediators during cell proliferation and differentiation induced by HoxB4, which leads to increase expression of Cyclin D1 and G1 shortening. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:32000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. |
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