Technical Data
H7023-15R3
HOXB8 (Homeobox Protein Hox-B8, Homeobox Protein Hox-2.4, Homeobox Protein Hox-2D, HOX2D)
Description:
HOXB8 is a member of the Antp homeobox family. It is a sequence specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior posterior axis during development. Increased expression of this gene is associated with colorectal cancer. Mice that have had the murine ortholog of this gene knocked out exhibit an excessive pathologic grooming behavior. This behavior is similar to the behavior of humans suffering from the obsessive compulsive spectrum disorder trichotillomania.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20°CBlue IceHumanRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa110-125 (CKLAAASGLGEEAEGS) of human HOXB8 protein.
Purity:
Serum.
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes human Hox B8. Species sequence homology: bovine, canine, mouse, rat. Species sequence homology: chicken.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Knoepfler,P.S., Sykes,D.B., Pasillas,M. and Kamps,M.P. HoxB8 requires its Pbx-interaction motif to block differentiation of primary myeloid progenitors and of most cell line models of myeloid differentiation. Oncogene 20 (39), 5440-5448 (2001). 2. Fujino,T., Yamazaki,Y., Largaespada,D.A., Jenkins,N.A., Copeland,N.G., Hirokawa,K. and Nakamura,T. Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes. Exp. Hematol. 29 (7), 856-863 (2001). 3. Greer,J.M. and Capecchi,M.R. Hoxb8 is required for normal grooming behavior in mice. Neuron 33 (1), 23-34 (2002).