Technical Data
H7023-16A
HOXB13 (Homeobox Protein Hox-B13)
Description:
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.

Applications:
Suitable for use in ELISA. Other applications not tested.

Recommended Dilution:
ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
TypeIsotypeCloneGrade
PabIgGSerum
SizeStorageShippingSourceHost
100ul-20CBlue IceHumanRabbit
Concentration:
Not determined.
Immunogen:
Synthetic peptide corresponding to aa259-275 (QITIWFQNRRVKEKKVL) of human HOXB13.
Purity:
Serum.
Form
Supplied as a liquid, 0.025% sodium azide, 50% glycerol.
Specificity:
Recognizes human Homeobox protein B13. Sequence Homology: HOXA13 and HOXC13: 88%. Species Crossreactivity: bovine, chimpanzee, canine, mouse, rat. Species sequence homology: Axoloti.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
1. Jung,C., Kim,R.S., Zhang,H.J., Lee,S.J. and Jeng,M.H. HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling. Cancer Res. 64 (24), 9185-9192 (2004). 2. Jung,C., Kim,R.S., Lee,S.J., Wang,C. and Jeng,M.H. HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4. Cancer Res. 64 (9), 3046-3051 (2004).